| Date & Time | Favorite | Spread | Underdog |
| 11/21 8:30 ET | Oakland (At Mexico City) | -6 | Houston |
| Date & Time | Favorite | Spread | Underdog |
| 11/24 12:30 ET | At Detroit | -2.5 | Minnesota |
| 11/24 4:30 ET | At Dallas | -7 | Washington |
| 11/24 8:30 ET | Pittsburgh | -3 | At Indianapolis |
| 11/27 1:00 ET | At Houston | PK | San Diego |
| 11/27 1:00 ET | Tennessee | -1.5 | At Chicago |
| 11/27 1:00 ET | At Buffalo | -7 | Jacksonville |
| 11/27 1:00 ET | At Baltimore | -3.5 | Cincinnati |
| 11/27 1:00 ET | At Atlanta | -4 | Arizona |
| 11/27 1:00 ET | At Miami | -8 | San Francisco |
| 11/27 1:00 ET | At New Orleans | -6.5 | Los Angeles |
| 11/27 1:00 ET | NY Giants | -6.5 | At Cleveland |
| 11/27 4:05 ET | Seattle | -5.5 | At Tampa Bay |
| 11/27 4:25 ET | At Oakland | -4 | Carolina |
| 11/27 4:25 ET | At Denver | -3.5 | Kansas City |
| 11/27 8:30 ET | New England | -8.5 | At NY Jets |
| 11/28 8:30 ET | At EAGLES | -3 | Green Bay |
