By Steve Kelly

Former President Barack Obama sat down virtually with Charles Barkley and Shaquille O’Neal to educate the public about some of the misconceptions about the vaccine.

But, before he got down to business … Obama had a little fun at Shaq and Barkley’s expense!

Obama razzed Chuck for his famous gambling habit and joked with Shaq about how the Big Man endorses every business on the planet!

And then came the fat joke …

Obama congratulated Barkley on his daughter’s recent wedding — and brought up how Charles mentioned how he wanted to slim down for the event.

“You also felt like you need to get in shape because The Hora (the traditional Jewish dance) … when you’re lifting the chair, nobody could do that at your current weight!”

Click to watch this TMZ clip: