Ryan Mathews’ huge game last Sunday against the Jets makes him a good pick in Week 4.
Quarterbacks
| Rk | +/- | Tr | Player | Tm | Opp |
| 1 | 1 | Aaron Rodgers | GB | @SF | |
| 2 | 2 | Peyton Manning | DEN | MIN | |
| 3 | 2 | Carson Palmer | ARI | STL | |
| 4 | INJ | Andrew Luck | IND | JAX | |
| 5 | 2 | Joe Flacco | BAL | @PIT | |
| 6 | 2 | Sam Bradford | PHI | @WAS | |
| 7 | 2 | Matt Ryan | ATL | HOU | |
| 8 | 3 | Russell Wilson | SEA | DET | |
| 9 | 3 | Andy Dalton | CIN | KC | |
| 10 | INJ | Drew Brees | NO | DAL | |
| 11 | 3 | Derek Carr | OAK | @CHI | |
| 12 | 3 | Cam Newton | CAR | @TB | |
| 13 | 3 | Philip Rivers | SD | CLE | |
| 14 | 4 | Tyrod Taylor | BUF | NYG | |
| 15 | 4 | Luke McCown | NO | DAL | |
| 16 | 4 | Teddy Bridgewater | MIN | @DEN | |
| 17 | 4 | Brandon Weeden | DAL | @NO | |
| 18 | 5 | Eli Manning | NYG | @BUF | |
| 19 | 5 | Kirk Cousins | WAS | PHI | |
| 20 | 5 | Alex Smith | KC | @CIN | |
| 21 | 5 | Ryan Fitzpatrick | NYJ | @MIA | |
| 22 | 5 | Ryan Tannehill | MIA | NYJ | |
| 23 | 5 | Michael Vick | PIT | BAL | |
| 24 | INJ | Josh McCown | CLE | @SD | |
| 25 | 5 | Blake Bortles | JAX | @IND | |
| 26 | INJ | Jay Cutler | CHI | OAK | |
| 27 | 6 | Ryan Mallett | HOU | @ATL | |
| 28 | 6 | Jameis Winston | TB | CAR | |
| 29 | 6 | Colin Kaepernick | SF | GB | |
| 30 | 6 | Matthew Stafford | DET | @SEA | |
| 31 | 6 | Nick Foles | STL | @ARI | |
| 32 | 6 | Jimmy Clausen | CHI | OAK | |
| — | OUT | Ben Roethlisberger | PIT | BAL | |
| — | IR-R | Tony Romo | DAL | @NO | |
| — | BYE | Tom Brady | NE | BYE | |
| — | BYE | Marcus Mariota | TEN | BYE |
Running backs
| Rk | +/- | Tr | Player | Tm | Opp |
| 1 | 1 | Adrian Peterson | MIN | @DEN | |
| 2 | 1 | Frank Gore | IND | JAX | |
| 3 | 2 | Jamaal Charles | KC | @CIN | |
| 4 | 2 | Mark Ingram | NO | DAL | |
| 5 | 2 | Matt Forte | CHI | OAK | |
| 6 | 2 | Eddie Lacy | GB | @SF | |
| 7 | 2 | Joseph Randle | DAL | @NO | |
| 8 | 2 | Le’Veon Bell | PIT | BAL | |
| 9 | 3 | Karlos Williams | BUF | NYG | |
| 10 | 3 | Melvin Gordon | SD | CLE | |
| 11 | INJ | Marshawn Lynch | SEA | DET | |
| 12 | 3 | Ryan Mathews | PHI | @WAS | |
| 13 | 3 | Alfred Blue | HOU | @ATL | |
| 14 | 3 | Chris Johnson | ARI | STL | |
| 15 | 3 | Isaiah Crowell | CLE | @SD | |
| 16 | INJ | Jonathan Stewart | CAR | @TB | |
| 17 | INJ | Devonta Freeman | ATL | HOU | |
| 18 | INJ | LeSean McCoy | BUF | NYG | |
| 19 | 4 | Latavius Murray | OAK | @CHI | |
| 20 | INJ | Arian Foster | HOU | @ATL | |
| 21 | 4 | Giovani Bernard | CIN | KC | |
| 22 | 5 | Danny Woodhead | SD | CLE | |
| 23 | 5 | Bilal Powell | NYJ | @MIA | |
| 24 | 5 | Theo Riddick | DET | @SEA | |
| 25 | 5 | Lance Dunbar | DAL | @NO | |
| 26 | 5 | David Johnson | ARI | STL | |
| 27 | INJ | Chris Ivory | NYJ | @MIA | |
| 28 | 5 | T.J. Yeldon | JAX | @IND | |
| 29 | INJ | C.J. Anderson | DEN | MIN | |
| 30 | 6 | Carlos Hyde | SF | GB | |
| 31 | 6 | Matt Jones | WAS | PHI | |
| 32 | INJ | Jonathan Grimes | HOU | @ATL | |
| 33 | 7 | Jeremy Hill | CIN | KC | |
| 34 | 7 | Alfred Morris | WAS | PHI | |
| 35 | 7 | Darren Sproles | PHI | @WAS | |
| 36 | 7 | Justin Forsett | BAL | @PIT | |
| 37 | 7 | Ronnie Hillman | DEN | MIN | |
| 38 | 7 | Ameer Abdullah | DET | @SEA | |
| 39 | 7 | Tre Mason | STL | @ARI | |
| 40 | 7 | Lamar Miller | MIA | NYJ | |
| 41 | 8 | Shane Vereen | NYG | @BUF | |
| 42 | 8 | Darren McFadden | DAL | @NO | |
| 43 | 8 | Thomas Rawls | SEA | DET | |
| 44 | 8 | Andre Williams | NYG | @BUF | |
| 45 | 8 | C.J. Spiller | NO | DAL | |
| 46 | 8 | Doug Martin | TB | CAR | |
| 47 | 8 | Todd Gurley | STL | @ARI | |
| 48 | 9 | Jonas Gray | MIA | NYJ | |
| 49 | 9 | Juwan Thompson | DEN | MIN | |
| 50 | 9 | Joique Bell | DET | @SEA | |
| 51 | 9 | DeAngelo Williams | PIT | BAL | |
| 52 | 10 | James Starks | GB | @SF | |
| 53 | 10 | Charles Sims | TB | CAR | |
| 54 | 10 | Khiry Robinson | NO | DAL | |
| 55 | 10 | Roy Helu | OAK | @CHI | |
| 56 | 10 | Fred Jackson | SEA | DET | |
| 57 | INJ | Lorenzo Taliaferro | BAL | @PIT | |
| 58 | 10 | Damien Williams | MIA | NYJ | |
| 59 | 10 | Rashad Jennings | NYG | @BUF | |
| 60 | 10 | Duke Johnson | CLE | @SD | |
| 61 | 10 | Marcel Reece | OAK | @CHI | |
| 62 | 10 | Toby Gerhart | JAX | @IND | |
| 63 | 10 | Josh Robinson | IND | JAX | |
| 64 | 10 | Jerick McKinnon | MIN | @DEN | |
| 65 | INJ | Mike Tolbert | CAR | @TB | |
| 66 | 11 | Benny Cunningham | STL | @ARI | |
| 67 | 11 | Javorius Allen | BAL | @PIT | |
| 68 | 11 | Mike Davis | SF | GB | |
| 69 | 11 | Jeremy Langford | CHI | OAK | |
| 70 | 11 | Matt Asiata | MIN | @DEN | |
| 71 | 11 | Knile Davis | KC | @CIN | |
| 72 | 11 | Anthony Dixon | BUF | NYG | |
| 73 | 11 | Cameron Artis-Payne | CAR | @TB | |
| 74 | INJ | Fozzy Whittaker | CAR | @TB | |
| 75 | 11 | Taiwan Jones | OAK | @CHI | |
| 76 | 11 | Dri Archer | PIT | BAL | |
| 77 | 11 | Jacquizz Rodgers | CHI | OAK | |
| 78 | 11 | Chris Polk | HOU | @ATL | |
| 79 | 11 | Branden Oliver | SD | CLE | |
| 80 | 11 | LaMichael James | MIA | NYJ | |
| 81 | 11 | Jarryd Hayne | SF | GB | |
| 82 | 11 | Bobby Rainey | TB | CAR | |
| 83 | 11 | Bernard Pierce | JAX | @IND | |
| 84 | 11 | Darrel Young | WAS | PHI | |
| 85 | 11 | Zach Zenner | DET | @SEA | |
| 86 | 11 | Zac Stacy | NYJ | @MIA | |
| 87 | 11 | Rex Burkhead | CIN | KC | |
| 88 | 11 | Donald Brown | SD | CLE | |
| 89 | 11 | Jordan Todman | PIT | BAL | |
| 90 | 11 | Ka’Deem Carey | CHI | OAK | |
| 91 | 11 | Christine Michael | DAL | @NO | |
| 92 | 11 | Charcandrick West | KC | @CIN | |
| — | INJ | Reggie Bush | SF | GB | |
| — | INJ | Denard Robinson | JAX | @IND | |
| — | INJ | Andre Ellington | ARI | STL | |
| — | INJ | DeMarco Murray | PHI | @WAS | |
| — | INJ | Robert Turbin | CLE | @SD | |
| — | INJ | Tevin Coleman | ATL | HOU | |
| — | P▲ | Stevan Ridley | NYJ | @MIA | |
| — | IR-R | David Cobb | TEN | BYE | |
| — | IR-R | Jay Ajayi | MIA | NYJ | |
| — | BYE | Dion Lewis | NE | BYE | |
| — | BYE | LeGarrette Blount | NE | BYE | |
| — | BYE | Brandon Bolden | NE | BYE | |
| — | BYE | Travaris Cadet | NE | BYE | |
| — | BYE | James White | NE | BYE | |
| — | BYE | Bishop Sankey | TEN | BYE | |
| — | BYE | Dexter McCluster | TEN | BYE | |
| — | BYE | Terrance West | TEN | BYE | |
| — | BYE | Antonio Andrews | TEN | BYE |
